客户文章-质粒篇
● International Journal of Oral Science(IF 14.9).Zhang DX.(2024). Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK.[山东大学,AdV5-CMV-GFP-LC3,AdV5-GFP-RFP-LC3,CAL 27细胞(人舌鳞癌细胞) MOI 100,口腔鳞状细胞癌.]
● Biol Psychiatry. (IF=12.095). Zhao D, et al. (2019). RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.[厦门大学 Ad-PSD-95 & Ad-control GFP 阿尔兹海默症]
● J Clin Endocrinol Metab. (IF=5.399). Li M, et al. (2019). The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.[山东大学 Ad-HMGA2 多囊卵巢综合征]
● Int J Cardiol. (IF=3.229). Wu B, et al. (2018). Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.[湖北医药学院 Ad-Meox1 血管重塑]
● Life Sci. (IF=6.304). He M, et al. (2018). In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer.[北京大学 Ad-FUZ & Ad-NC 非小细胞肺癌]
● Cell Death Dis. (IF=6.304). Sun S, et al. (2017). Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.[华中科技大学同济医学院附属同济医院 Ad-PDK4 肿瘤代谢]
● Molecular Medicine Reports. (IF=2.1). Zhang S, et al. (2017). PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells. [南方医科大学南方医院 Ad-PAR1 热应激诱导HUVEC凋亡]
● Hepatology. (IF=14.679). Xiang D, et al. (2017). Shp2 promotes liver cancer stem cell expansion by augmenting β-atenin signaling and predicts chemotherapeutic response of patients.[东方肝胆外科医院 AdShp2 and AdGFP 肝癌]
● Cancer Letters. (IF=7.36). Wang Z , et al . (2017). CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrinβ1/FAK/AKT signaling.[中山大学附属第一医院 Ad-CXCL1胃癌]
● Gene. (IF=2.984). Zhang J W, et al. (2017). Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function.[北京大学第一医院 Ad-CMTM5-v1& Ad-mock 冠心病]
● Cell Death Dis. (IF=6.304). Zheng Y, et al. (2017). Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. [上海交通大学医学院 & 中国科学院上海生命科学研究院 Ad-Atg5 缺血性心脏病]
● Oncoimmunology. (IF=5.869). Wang H, et al. (2016). Interactions between colon cancer cells and tumor-infiltrated macrophages depending on cancer cell-derived colony stimulating factor 1. [山东齐鲁医院 Ad-hCSF1瘤内注射 结肠癌]
● Basic Res Cardiol. (IF=11.981). Sun Z, et al. (2016). Cross-talk between macrophages and atrial myocytes in atrial fibrillation.[浙江大学医学院附属第一医院 Ad-QKI 心房纤颤]
● Mol Carcinog. (IF=3.825). Wang J, et al. (2016). Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice.[复旦大学 Ad-TFPI & Ad-GFP 肿瘤]
● Frontiers in Immunology. (IF 8.786). Huang et.al. (2023). FGL2 deficiency alleviates maternal
inflammation-induced blood-brain barrier damage by blocking PI3K/NF-kB mediated
endothelial oxidative stress. [华中科技大学同济医学院附属同济医院 Ad-FGL2-miRNA 血脑屏障]
● Hypertension. (IF=9.897).Junni Wang,et.al.(2021).MicroRNA-87 4-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury. [浙江大学第一附属医院 Ad-miR-874-3p 肾纤维化]
● Stem Cells Int. (IF=3.869). Li X, et al. (2019). MicroRNA-150 Modulates Adipogenic Differentiation of Adipose-Derived Stem Cells by Targeting Notch3.[中国医科大学 Ad-miR-150 脂肪源性干细胞]
● Oncotarget. (IF=5.168). Tian S, et al. (2017). miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.[贵州医科大学附属医院 Ad-miR-138-5p & Ad-miR-NC 胰腺癌细胞自噬]
● Cell Death & Disease (IF 8.1). Peng et.al. (2024). Tripartite motif 8 promotes the progression of
hepatocellular carcinoma via mediating ubiquitination of HNF1α. [上海长征医院谢渭芬、张鑫团队 Ad-HNF1α(K197R) 肝癌]
● Cell & Bioscience(IF 7.9).Lei ZY.(2024). Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation.[中山大学附属第三医院,Ad-CMV-Med1,尾静脉注射,3.6×10^9 PFU,急性肝衰竭]
● Cell Communication and Signaling ( IF 8.2 ). Ma et.al.
(2024). Low concentrations of saracatinib promote
definitive endoderm differentiation through inhibition of FAK-YAP signaling
axis. [西安交通大学第一附属医院丁小明团队 内胚层分化]
● Redox Biology (IF 11.4). Shao et.al. (2024). FOXO1 regulates RUNX2 ubiquitination through
SMURF2 in calcific aortic valve disease. [华中科技大学同济医学院附属协和医院董念国、李飞研究团队联合南京医科大学第一附属医院研究团队 钙化性主动脉瓣疾病]
● Molecular Metabolism (IF 8.1).Li J, et.al. (2024). Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.[武汉大学人民医院 Ad-DNER、Ad-DNER (Tyr 677 to Ala)、Ad-HA 肝糖异生]
●Journal of Nanobiotechnology (IF 10.2).Ye L, et.al. (2024). Modulation of alveolar macrophage and mitochondrial fitness by medicinal plantderived nanovesicles to mitigate acute lung injury and viral pneumonia.[浙江树人学院转化医学研究院 Ad-ACE2 急性肺损伤和病毒性肺炎]
●Nature Communications(IF 16.6).Wang SJ.(2024). Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity.[中山大学、广州医科大学附属第一医院,Ad5-GALNT3/T7,Ad5-EV,人肺腺癌细胞Calu-3,MOI 1000,新冠病毒防御机制]
● VIEW(IF 8.6).Zhu JW.(2023). The PES1/FOXM1 heterodimer suppresses TCF21 and ERβ expression in ovarian endometriosis.[北京大学第一医院,Ad-Pes1,Ad-vector,体内注射109pfu,子宫内膜异位症.]
● Acta Pharmaceutica Sinica B (IF 14.5). Rong et.al.
(2024). Inhibition of xanthine oxidase alleviated
pancreatic necrosis via HIF1α-regulated LDHA and NLRP3 signaling pathway in
acute pancreatitis. [华西医院杜丹、夏庆团队,Ad- XDH,胰腺炎]
● Cell Metabolism(IF 29).Dong YM.(2024). A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.[华中科技大学附属同济医院,Ad-shRNA-Slc40a1(pAd-4 in 1 shRNA),骨髓源性巨噬细胞 MOI 200.骨质疏松]
● Advanced Science(IF 15.1).Ding L.(2024). Beta-Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5.[山东大学基础医学院,Ad-CMV-Gnas,Ad-CMV-Tipe1,MIN6细胞/Islets细胞,2型糖尿病.]
● Journal of Medical Virology (IF 12.7). Yu et.al. (2023). SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species. [华中科技大学同济医学院基础医学院,Ad5-S2NP]
●BMC Biology(IF 5.4).You WJ.(2023). GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.[浙江大学,Ad-Gadd45a,Ad-Ctrl.小鼠/猪皮下脂肪细胞.脂肪代谢]
●J Clin Invest,(IF 15.9).Yang ZY.(2023). Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress.[第四军医大学,Ad-CTCF、Ad-Ctrl,人脐静脉内皮细胞(HUVECs),MOI 200,肿瘤血管]
● Metabolism,(IF 9.8).Hu YT.(2023). Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.[北京大学医学部基础医学院、北京大学人民医院,AAV8-FPR1、AAV8-GFP,尾静脉注射,肝脂肪代谢]
●Acta Pharmacologica Sinica(IF8.2).Huang YM, et.al. (2023). Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation.[广州医科大学 Ad-hPar3L、Ad-GFP 动脉粥样硬化性心血管疾病]
●Journal of Translational Medicine (IF=7.4).Xiong W, et.al. (2023). UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.[华中科技大学同济医学院附属协和医院 Ad-UCP1 、Ad-Ctrl 肾间质纤维化]
● Free Radical Biology and Medicine. (IF 7.4). Zhang et.al. (2023). Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis. [第四军医大学基础医学院、第四军医大学西京医院,AAV和腺病毒过表达载体AAV9-cTNT-frataxin,Ad-Frataxin 心脏]
● JACC-Basic to Translational Science,(IF 9.531). Zhu ZY.(2023). Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis.[浙江大学医学院附属第二医院 Adv-shGDF-11,心肌细胞(CMs),MOI=200,心力衰竭]
●Journal of Molecular Medicine,(IF 5.606). Shao SY.(2023). Never in mitosis gene Arelated kinase6 deficiency deterioratesdiabetic cardiomyopathy via regulating heat shock protein 72.[郑州大学第一附属医院Ad-NEK6,MOI=50,心肌细胞,糖尿病心肌病]
●Signal Transduction and Targeted Therapy(IF 39.3).Chunsik Lee. et.al.(2023). VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway[中山大学中山眼科中心,瑞典卡罗林斯卡研究院联合复旦大学附属眼耳鼻喉科医院Ad-FGFR1 WT,Ad-FGFR1 Y463F, Ad-FGFR1 Y585F,Ad-FGFR1 Y653F人脐静脉内皮细胞-HUVECs,MOI=10,血管]
●iScience (IF 6.107).Li YJ.(2023).Phosphodiesterase type 10A inhibitor attenuates lung 1 fibrosis by targeting myofibroblast activation[浙江大学医学院附属邵逸夫医院 pADM-PDE10A,人胚肺成纤维细胞(HFL-1),肺部纤维化]
●ISCIENCE. (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from
obesity-induced glucose intolerance via improving glucose-stimulated insulin
secretion by beta cells. [中山大学附属第一医院 AAV和腺病毒过表达载体 胰腺]
● Journal of Translational Medicine. (IF=8.44). Zhang RN, et.al. (2023). The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy.[湖北医药学院 Ad-NFATc1、Ad-NFATc2、Ad-shNFATc3、Ad-shNFATc4、Ad-Null 腓骨肌萎缩症]
●J CELL COMMUN SIGNAL.(IF=5.908).Liu X, et.al. (2023). Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF‑α/STAT3/autophagy axis.[武汉协和医院 Ad-Sam68 钙化主动脉瓣疾病]
●Journal of Nutritional Biochemistry.(IF=6.117)Liu J, et.al. (2023). Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.[华中科技大学同济医学院公共卫生学院 Ad-Frataxin 酒精性肝病]
●Acta Pharmacologica Sinica. (IF 7.169) Guo et.al. (2023). JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit. [山东第一医科大学 JMJD6 腺病毒过表达载体 心肌肥厚]
● Journal of Neuroinflammation. (IF 9.587) Qian Xia et.al. (2022). Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1. [华中科技大学同济医院 SIRT5腺病毒过表达和干扰载体 神经炎症]
● Ecotoxicology and Environmental Safety. (IF 7.129) Jingjing Zhang et.al. (2023). The inhibition of TRPML1 TFEB leads to lysosomal biogenesis disorder contributes to developmental fluoride neurotoxicity. [新疆石河子大学 TFEB腺病毒过表达载体 氟神经毒性]
● ARTERIOSCL THROM VAS(IF=10.514).Shu Liu,et.al.(2022).Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein [中国医学科学院阜外医 AdV-TPRG1-AS1和AdVMYH9 动脉粥样硬化]
●Journal of Cachexia, Sarcopenia and Muscle.(IF=12.063).You W , et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.[浙江大学动物科学学院 Ad-GADD45A 肌内脂肪沉积]
● Free Radical Biology and Medicine. (IF 8.101). Liu Y, et.al. (2022). LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway.[郑州大学第一附属医院 Ad-LRRK2 & Ad-LRRK2 D1994A & Ad-NC 心肌梗死]
● Journal of Molecular and Cellular Cardiology.(IF=5.763).Wang S, et.al. (2022). Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair.[中山大学中山医学院&南方医科大学珠江医院 Ad-SIRT6 & Ad-GFP 血管钙化]
● Molecular Neurobiology. (IF=5.682). Zhou B, et.al. (2022). FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.[南昌大学第一附属医院 Ad-FUS & Ad-FUS-K510Q 肌萎缩侧索硬化症]
● Cell and Bioscience. (IF=9.584). Mao M, et.al. (2022). SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury. [华中科技大学附属同济医院&郑州大学附属中心医院 Ad-SENP6 & Ad-vector 脑中风]
● Arterioscler Thromb Vasc Biol.(IF=10.514). Ren X, et.al. (2022). Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein. [中国医学科学院阜外医院 Ad-TPRG1-AS1 & Ad-MYH9 动脉粥样硬化性心血管]
● Pharmacol Res.(IF=10.334). Zhu S, et al. (2022). The miR-145-MMP1 axis is a critical regulator for imiquimod-induced cancer stemness and chemoresistance. [吉林大学第一医院转化医学研究所 Ad-miR-145 & Ad-control 肿瘤干性]
● Acta Biomaterialia.(IF=10.633). Wang F, et.al. (2022). Adipose-derived stem cells with miR-150-5p inhibition laden in hydroxyapatite/tricalcium phosphate ceramic powders promote osteogenesis via regulating Notch3 and activating FAK/ERK and RhoA. [中国医科大学 Ad-miR-150-5p & Ad-NC 骨质疏松症]
● Molecular Cancer. (IF=41.444).Lei Liu,et.al.(2021).KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1. [山东大学Ad-KDM6A & Ad-GFP 膀胱癌]
● Signal Transduction and Targeted Therapy.(IF=38.104).Suowen Xu, et.al.(2021).The zinc fifinger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction.[中国科技大学 Ad-KLF2 & Ad-GFP 内皮功能障碍]
● Redox Biology .(IF=10.787).Yaqian Huang,et.al.(2021).Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling. [北京大学第一医院 Ad-AAT1 血管重塑]
● Theranostics.(IF=38.104).Yan Jiang, et.al.(2021). Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis. [复旦大学Ad-Jmjd3 & Ad-Jmjd3-mut肝纤维化]
● Nat Commun. (IF=17.694). Liu R, et.al. (2022). MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake. [山东第一医科大学附属眼科研究所Ad-GFP&Ad-CMV-Glut2&Ad-insulin 1-miR-21 胰腺β细胞]
● Cell Metab. (IF=27.287). Zhou N, et.al. (2022). Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. [北京大学&山一大附属省立医院 Ad-PPARd &Ad-OTUD3&Ad-control 糖脂代谢]
● Genes & Diseases. (IF=7.103). Luo J, et.al. (2022). PLSCR1 Promotes Apoptosis and Clearance of Retinal Ganglion Cells in Glaucoma Pathogenesis. [中山大学Ad-PLSCR1&Ad-control 青光眼]
●
J Cell Physiol. (IF=5.546) . Wang M, et al. (2021) . Lack of Mof reduces acute liver injury by enhancingtranscriptional activation of Igf1. [过表达/干扰 急性肝损伤]
●
Front Cell Dev Biol. (IF=5.201) . Gu J, et al. (2021) . CFTR Deficiency Affects Glucose
Homeostasis via Regulating GLUT4 Plasma Membrane Transportation. [过表达 成肌细胞]
●
Front Immunol. (IF=5.085) . Wu L, et al. (2021) . EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice. [过表达 狼疮肾炎]
●
[4]Oxid Med Cell Longev. (IF=5.076) . Gao Y, et al. (2021) .Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress. [过表达 心肌]
●
J Cell Mol Med. (IF=4.486) . Lei W,et al. (2021) . MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway. [过表达 心肌]
●
J Biol Chem. (IF=4.238) . Zhang Z,et al. (2021) . The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. [过表达/干扰 肝脏]
●
J Anim Sci Biotechnol. (IF=4.167) . Liu J, et al. (2021) . Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses. [过表达 脂肪细胞]
●
Aging. (IF=4.831) .Chen Y, et al. (2020). Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats[自噬双标 术后认知功能障碍].
● Elife Tool. (IF=7.08). Wu L, et al. (2019). PARIS, an optogenetic method for functionally mapping gap junctions.[北京大学 Ad-CMV-pHluorinCAAX 缝隙连接探针]
● Cell Death Dis. (IF=6.304). Su Y, et al. (2019). MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis.[中山大学眼科中心 & 中山大学中山医学院 Ad-TAB2 & Ad-NEMO HUVECs 动脉粥样硬化]
● EBioMedicine. (IF=5.736). Wang K, et al. (2019). TGF-beta1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.[温州医科大学附属台州医院 Ad-p65 & Ad-EV 肝纤维化]
● Arthritis Res Ther. (IF=4.103). Zeng J, et al. (2019). Interferon-alpha exacerbates neuropsychiatric phenotypes in lupus-prone mice.[上海交通大学医学院附属仁济医院 Adv-IFN-α & Adv-ctrl系统性红斑狼疮]
● Oncogene. (IF=7.971). Yu M, et al. (2018). Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility. [北京大学深圳研究生院 Ad-AXL 胶质母细胞瘤]
● Cell Death Discov. (IF=4.114). Zhang SQ, et al. (2018). Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3beta activity.[香港浸会大学 Ad-GSK3β (S9A) 神经干细胞NSCs]
● Int J Mol Med. (IF=3.098). Zhang L, et al. (2018). Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-kappaB pathway.[武汉大学人民医院张杰团队 Ad-Lefty-1 肾脏炎]
● Redox Biol. (IF=9.986). Jin Q, et al. (2018). DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.[中国人民解放军总医院 Ad-DUSP1 & Ad-ctrl 心脏缺血再灌注损伤]
● Cell Physiol Biochem. (IF=5.5). Wang Y, et al. (2018). Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. [浙江大学医学院附属第二医院Ad- mCherry-GFP-LC3 心脏重塑]
● Brain,Behavior,and Immunity. (IF=6.633). Zhou Y.T, et al. (2017). Interleukin-1βimpedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion.[浙江大学 Ad-IL-1R1-RFP & Ad-RFP 皮层下缺血性血管性痴呆SIVD]
● J Pharmacol Sci. (IF=2.835). Li J, et al. (2016). PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy.[中山大学 Ad-PKCζ & Ad-GFP心肌肥厚]
● Arthritis Rheumatol. (IF=9.586). Han X, et al. (2016). MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells.[上海交通大学医学院 Ad-IFNα5 狼疮肾炎]
● Sci Rep. (IF=3.998). Zhang H, et al. (2016). Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor. entific Reports.[北京大学第一医院 Ad-AAT1 3T3-L1 cell 脂肪组织慢性炎症]
● Mol Cell Biol. (IF=3.611). Wu C, et al. (2016). Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity.[南方科技大学 Ad-Cre RNA聚合酶I转录活性]
● Molecular Metabolism (IF 8.1).Li J, et.al. (2024). Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.[武汉大学人民医院 Ad-U6-shDNER、Ad-U6-shRNA control 肝糖异生]
● ACS Applied Materials & Interfaces(IF 9.5).Yu KX.(2023). Cancer-Erythrocyte Membrane-Mimicking Fe3O4 Nanoparticles and DHJS for Ferroptosis/ Immunotherapy Synergism in Tumors.[华中科技大学同济医学院附属同济医院、湖北科技学院、武汉大学中南医院,Ad-shRNA-Nrf2,Ad-shRNA-con.HOS细胞(人骨肉瘤细胞)MOI 50.骨肉瘤]
● Pharmacol Res.(IF=10.334). Dong Y, et.al. (2022). Blocking the cytohesin-2/ARF1 axis by SecinH3 ameliorates osteoclast-induced bone loss via attenuating JNK-mediated IRE1 endoribonuclease activity. [华中科技大学附属同济医院 Ad-4in1-shCytohesin-1 ;Ad-4in1-shCytohesin-2;Ad-4in1-shCytohesin-3;Ad-4in1-shNC 骨质疏松]
● Mol Ther. (IF=12.910). Zheng H, et al. (2022) . CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. [南方医科大学 Ad-shcircSamd4 & Ad-NC 心肌梗死]
● Biomedicine & Pharmacotherapy.(IF=7.419). Hong Q, et.al. (2022). Trimethylamine-N-oxide (TMAO) promotes balloon injury-induced neointimal hyperplasia via upregulating Beclin1 and impairing autophagic flux .[南方医科大学珠江医院 Ad-shBeclin1 & Ad-shNC 血管重塑]
● Journal of Cellular and Molecular Medicine. (IF=4.486). Wang, et al. (2020). Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. [华中科技大学同济医学院同济医院骨科 murine PFKFB3 Adenoviruses-4 in 1 shRNA-GFP 骨髓源性巨噬细胞BMMs MOI=50 破骨细胞相关疾病]
● EBioMedicine. (IF=5.736. Li, et al. (2019). Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway.[南方医科大学南方医院 AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP 人脐静脉内皮细胞HUVECs MOI=100 新血管形成]
● Bone. (IF=4.147). Zhao, et al. (2018). YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.[华中科技大学同济医学院同济医院骨科 murine YAP1 Adenoviruses-4 in 1 shRNA-GFP 骨髓源性巨噬细胞BMMs & RAW264.7 cells 破骨细胞生成]
● Cardiovascular Research. (IF=8.168. Li, et al. (2018). Loss of AZIN2 splice variant facilitates
endogenous cardiac regeneration.[南方医科大学南方医院 AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP 心肌细胞CMs MOI=100 & 大鼠心肌注射 心脏再生]
● Br J Pharmacol. (IF=6.304). Ma Z.G, et al. (2016). Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKalpha signalling pathway. [武汉大学人民医院 Ad-shAMPKα2 心肌肥厚]
● Clin Sci . (IF=5.223). Ling Y, et al. (2016). Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux. [南方医科大学珠江医院 Ad-sh-Beclin1&Ad-NC 心肌缺血再灌注损伤]
● Int J Biol Sci. (IF=4.858). Ma Z G, et al. (2016). Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKalpha Signalling Pathway. [武汉大学人民医院 Ad-shAMPKα2 心肌肥厚]
● Nat Commun. (IF=12.121). Fu R, et al. (2020). Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. [中国药科大学Ad-βGal & Ad-Cre 骨质疏松]
● Cancer Sci. (IF=4.966). Wang X, et al. (2020). Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo. [南方科技大学Ad-LacZ & Ad-Cre 肺癌]
● Int. J. Mol. Sci. (IF=4.556). Xu, et al. (2020). Effective MSTN Gene Knockout by AdV-Delivered CRISPR/Cas9 in Postnatal Chick Leg Muscle.[上海交通大学 AdV-CRISPR system(pAdM-U6-gRNA1-U6-gRNA2-CMV-spCas9) 鸡胚成纤维细胞DF-1 MOI=1000 & 鸡肌肉注射 鸡骨骼肌的生长和发育]