The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

维真生物的产品仅限用于研究，不可用于包括人类体外诊断和治疗在内的其他用途。

维真生物的产品，不得修改和转售给任何第三方，未经维真生物的书面批准，不得将产品用于向其他第三方提供服务或用于制造商品化产品。

使用本产品应遵守以上条款以及网站http://www.vigenebio.cn上的产品相关规定。您有责任阅读、了解并遵守这些条款所产生的任何限制。